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WormBook is a comprehensive, open-access collection of original, peer-reviewed chapters covering topics related to the biology of Caenorhabditis elegans and other nematodes. Wormbook also contains: WormMethods, a collection of protocols for nematode researchers; WormHistory, personal perspectives on C. elegans research; and the Worm Breeder's Gazette, an informal, non-refereed, biannual newsletter for the interchange of ideas and information related to C. elegans and other nematodes. Additional chapters can be found in GENETICS.
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WormBook in GENETICS (new!)
C. elegans


News and Notes
July 14 2016
New chapter added to WormMethods
Working with dauer larvae, by Xantha Karp, has been added to the Behavior section of WormMethods as an ePub ahead of formal publication. This chapter summarizes dauer formation and describes methods for inducing and isolating dauers. Methods for obtaining pre- and post-dauer larvae are also provided.
May 24 2016
Small GTPase chapter updated
Small GTPases (2016), by David Reiner and Erik Lundquist, has been added to the Signal transduction section. This chapter updates the 2006 chapter by Lundquist with the same title. The new chapter provides an overview of small GTPases in C. elegans and gives details for members of the Ras, Rho, Rab, Arf, and Ran families. Atypical nematode members that fall outside these subfamilies are also discussed.
March 17 2016
New review of G protein signaling published
Neurotransmitter signaling through heterotrimeric G proteins: insights from studies in C. elegans, by Michael Koelle, has been added to the Signal transduction section as an ePub ahead of formal publication. This chapter updates, in part, Heterotrimeric G proteins in C. elegans, and focuses on signaling by Go, Gq, and Gs, their roles in inhibiting neurotransmitter release, and the details of their downstream signaling mechanisms.
March 10 2016
Message from Marty Chalfie
Please read Marty Chalfieā€™s letter to the Worm Community about the use of prepublication manuscript archives.This letter has been sent to the subscriber list for The Worm Breeder's Gazette and can be found here.
February 22 2016
Robert Stuart (Bob) Edgar, 1930-2016
We join the worm community in mourning Bob Edgar who died peacefully at home February 1. Bob helped establish C. elegans as a model organism and was an enthusiastic promoter of collegial nature of our field. Bob started The Worm Breeder's Gazette in 1975, and WormBook is proud to carry on his legacy. His full obituary can be read at http://news.ucsc.edu/2016/02/edgar-in-memoriam.html.
December 30 2015
New chapter added to Cell biology
The C. elegans eggshell, by Kathryn Stein and Andy Golden, has been released in the Cell biology section as an ePub ahead of formal publication. This chapter describes the structure, timeline of formation, and genetics of the eggshell.
December 22 2015
New and updated chapters pre-published
WormBook has instituted ePub ahead of formal publication. Our first two chapters in this format are: Meiosis, a new chapter by Kenneth Hillers, Verena Jantsch, Enrique Martinez-Perez, and Judith Yanowitz added to The germ line section, and Signaling in the innate immune response by Dennis Kim and Jonathan Ewbank, an updated chapter, added to the Signal transduction section.
November 4 2015
Announcement of WormBook in GENETICS
WormBook is excited to announce that we have partnered with The Genetics Society of America to publish new WormBook content in GENETICS. GENETICS will publish about 50 new chapters over the course of four years. Existing chapters will remain available at http://www.wormbook.org/, and several new and updated chapters will continue to be published at the site over the next six months. Letters describing these changes from Marty Chalfie and Iva Greenwald, who succeeds Marty as WormBook Editor-in-Chief, can be found here.
July 16 2015
Strongyloides chapter updated
The biology of Strongyloides spp., by Mark Viney and James Lok, has just been published in the Other nematodes section of WormBook. This chapter updates Strongyloides spp., by the same authors, and includes advances in our understanding of the genetics, genomics, regulatory pathways, and host immune response of these parasitic nematodes.
June 18 2015
Introductory chapter published
A Transparent Window into Biology: A Primer on Caenorhabditis elegans, by Ann Corsi, Bruce Wightman, and Marty Chalfie, has just been added to WormBook as a co-publication with GENETICS. This chapter discusses the basic biology, genetics, anatomy, genomics, ecology, and evolution of C. elegans. Key discoveries resulting from research using this organism are described, as is the strong collaborative nature of the worm community. We thank Tracey DePellegrin, Ruth Isaacson, and Elizabeth De Stasio of GENETICS for their dedication to this collaboration, as well as Editor-in-Chief Mark Johnston for his support of the project.
June 11 2015
Nuclear receptor chapter updated in WormBook
Nuclear receptor signal transduction in C. elegans, by Adam Antebi, has been added to the Signal transduction section of WormBook. This chapter updates his 2006 chapter, Nuclear hormone receptors in C. elegans. The updated chapter highlights recent advances on the best-studied nuclear receptors in the worm and discusses their role as regulators of life history, cell fate, and organogenesis, as well as their function in nutrient sensing, metabolism, and energy homeostasis.
April 30 2015
New chapter added to Molecular biology
Operon and non-operon gene clusters in the C. elegans genome, by Thomas Blumenthal, Paul Davis and Alfonso Garrido-Lecca, has been published in the Molecular biology section. This chapter discusses a variety of tight-linkage gene arrangements in the C. elegans genome, summarizes the current knowledge on several variations of operon processing, and describes non-operon gene clusters.
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