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WormBook is a comprehensive, open-access collection of original, peer-reviewed chapters covering topics related to the biology of Caenorhabditis elegans and other nematodes. Wormbook also contains: WormMethods, a collection of protocols for nematode researchers; WormHistory, personal perspectives on C. elegans research; and the Worm Breeder's Gazette, an informal, non-refereed, biannual newsletter for the interchange of ideas and information related to C. elegans and other nematodes.
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C. elegans


News and Notes
December 17 2014
Anthelmintic drug chapter updated
Anthelmintic drugs and nematicides: studies in Caenorhabditis elegans, by Lindy Holden-Dye and Robert Walker, an update of their chapter Anthelmintic drugs, has been added to the Disease models and drug discovery section. The chapter discusses the use of C. elegans as a model 'parasite', and reviews its use in the study of nematode control and as a platform for anthelmintic and nematicide discovery and development.
December 5 2014
DNA repair chapter updated
Replication and repair by Ann Rose has just been added to the Molecular biology section of WormBook. This chapter updates and greatly expands the 2006 chapter DNA repair by Nigel O'Neil and Ann Rose, and focuses on the use of C. elegans in the study of the Fanconi Anemia (FA) repair pathway.
November 4 2014
Epithelial junction chapter updated
Epithelial junctions, cytoskeleton, and polarity, by Gabriella Pásti and Michel Labouesse (an update of Epithelial junctions and attachments, by Michel Labouesse), is now available in the Cell biology section of WormBook. This chapter discusses the composition, assembly and remodeling of C. elegans cell-cell and hemidesmosome-like cell-extracellular matrix junctions, proteins that anchor the cytoskeleton, and mechanisms involved in establishing epithelial polarity.
October 30 2014
Overview of gene structure updated
Overview of gene structure in C. elegans, by John Spieth, Daniel Lawson, Paul Davis, Gary Williams, and Kevin Howe (an update of Overview of gene structure, by Spieth and Lawson), has just been added to the Genetics and genomics and Molecular biology sections. This chapter describes some of the ways in which gene structures are currently curated in WormBase, primarily focusing on transcribed regions of genes, and also includes an updated description of non-coding RNA genes.
October 20 2014
New issue of The Worm Breeder's Gazette available
Volume 20, Number 2 of The Worm Breeder's Gazette has been published. This issue highlights genome editing and includes 4 articles describing improvements in CRISPR/Cas9 technology, web resources useful for those experiments, and links to published papers in the field. The issue also includes descriptions of other useful tools for the worm community, a caution about the potential effects of bacto-peptone on worm behavior, and several other research summaries. There are also worm humor articles, worm art, and new lab announcements.
October 15 2014
New chapter added to Developmental control
Development and migration of the C. elegans Q neuroblasts and their descendants by Teije Middelkoop and Rik Korswagen has been published. This chapter gives an overview of what is currently known about the mechanisms that mediate and control the development and migration of the Q neuroblasts and their descendants.
August 5 2014
Mechanosensation methods updated
Assaying mechanosensation, by Martin Chalfie, Anne Hart, Catharine Rankin, and Miriam Goodman, has been published in the Behavioral assays section of WormMethods. In addition to updating and expanding assays for a variety of touch responses, the new chapter describes mechanical stimulation during electrical or optical recording.
June 26 2014
Mass spectrometry chapter available in WormMethods
Mass spectrometry-based shotgun proteomic analysis of C. elegans protein complexes, by Bryan Fonslow, James Moresco, Patricia Tu, Antti Aalto, Amy Pasquinelli, Andrew Dillin and John Yates, has been published in the Cell and molecular biology section of WormMehtods. This chapter describes the use of mass spectrometry-based shotgun proteomics coupled with co-immunoprecipitation to discover new interactions among proteins.
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